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A preventive medicine programme designed to significantly reduce the risk of heart attack and strokes

The Polypill Prevention Programme is a preventive medicine service to reduce the risk of first heart attacks and strokes. The service implements the Polypill approach in which a combination of commonly prescribed medications, that reduce several cardiovascular risk factors are administered together to individuals above a specified age without clinical cardiovascular disease and without selecting them on the basis of risk factors such as cholesterol or blood pressure.

The Polypill Prevention Programme began in 2006. Since no single pill was yet available, Polypill components were given separately, excluding aspirin because the risks of serious haemorrhage could outweigh the benefits. The Polypill formulation shown below was used.

Polypill components and doses Action on risk factor
Simvastatin 40mg Lowers serum cholesterol
Lisinopril 5mg  
Bendrofluazide 1.25mg Lowers blood pressure
Amlodipine 2.5mg  
Folic acid 0.8mg Lowers serum homocystine

The Polypill
by Wolfson Institute Website Manager © Queen Mary, University of London 2011
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Charterhouse Square, London EC1M 6BQ Tel: 020 7882 3850 Fax: 020 7882 6270